Mediator generation and signaling events in alveolar epithelial cells attacked by S. aureus α-toxin

Staphylococcus aureus alpha-toxin is a pore-forming bacterial exotoxin that has been implicated as a significant virulence factor in human staphylococcal diseases. In primary cultures of rat pneumocyte type II cells and the human A549 alveolar epithelial cell line, purified alpha-toxin provoked rapi...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2002-02, Vol.26 (2), p.L207-L214
Main Authors: ROSE, Frank, DAHLEM, Gabriele, GUTHMANN, Bernd, GRIMMINGER, Friedrich, MAUS, Ulrich, HÄNZE, Jörg, DUEMMER, Nils, GRANDEL, Ulrich, SEEGER, Werner, HOSSEIN ARDESCHIR GHOFRANI
Format: Article
Language:English
Subjects:
Bacteria
Bacterial diseases
Biological and medical sciences
Cellular biology
Experimental bacterial diseases and models
Infectious diseases
Lungs
Medical sciences
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Summary:Staphylococcus aureus alpha-toxin is a pore-forming bacterial exotoxin that has been implicated as a significant virulence factor in human staphylococcal diseases. In primary cultures of rat pneumocyte type II cells and the human A549 alveolar epithelial cell line, purified alpha-toxin provoked rapid-onset phosphatidylinositol (PtdIns) hydrolysis as well as liberation of nitric oxide and the prostanoids PGE2, PGI2, and thromboxane A2.
ISSN:1040-0605
1522-1504