Ectopic expression of IL-5 identifies an additional CD4+ T cell mechanism of airway eosinophil recruitment

CD4+ T cells have a critical role in the development of allergic pulmonary inflammation, including the recruitment of eosinophils to the airway lumen and interstitium. The expression of interleukin (IL)-5 by CD4+ cells has, in particular, often been lionized as the central link between allergic infl...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2002, Vol.26 (1), p.L99-L108
Main Authors: CROSBY, Jeffrey R, SHEN, H. H, BORCHERS, M. T, JUSTICE, J. P, ANSAY, T, LEE, J. J, LEE, N. A
Format: Article
Language:English
Subjects:
Allergic diseases
Allergies
Asthma
Biological and medical sciences
Cytokines
Genes
Immunopathology
Lungs
Medical sciences
Respiratory and ent allergic diseases
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Summary:CD4+ T cells have a critical role in the development of allergic pulmonary inflammation, including the recruitment of eosinophils to the airway lumen and interstitium. The expression of interleukin (IL)-5 by CD4+ cells has, in particular, often been lionized as the central link between allergic inflammation and the concomitant expansion or recruitment of eosinophils.
ISSN:1040-0605
1522-1504