Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction

Endothelin (ET)-1 contributes to the regulation of pulmonary vascular tone by stimulation of the ETA and ETB receptors. Although activation of the ETA receptor causes vasoconstriction, stimulation of the ETB receptors can elicit either vasodilation or vasoconstriction.

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2001-05, Vol.24 (5), p.L1040-L1048
Main Authors: IVY, D. Dunbar, MCMURTRY, Ivan F, YANAGISAWA, Masashi, GARIEPY, Cheryl E, LE CRAS, Timothy D, GEBB, Sarah A, MORRIS, Kenneth G, WISEMAN, Richard C, ABMAN, Steven H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cellular biology
Experiments
Medical research
Medical sciences
Pneumology
Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases
Respiratory system
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Description
Summary:Endothelin (ET)-1 contributes to the regulation of pulmonary vascular tone by stimulation of the ETA and ETB receptors. Although activation of the ETA receptor causes vasoconstriction, stimulation of the ETB receptors can elicit either vasodilation or vasoconstriction.
ISSN:1040-0605
1522-1504