Reduction of BCNU toxicity to lung cells by high-level expression of O6-methylguanine-DNA methyltransferase

1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) is an important cause of pulmonary toxicity. BCNU alkylates DNA at the O6 position of guanine.

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2001-04, Vol.24 (4), p.L755-L761
Main Authors: MIN WU, KELLEY, Mark R, HANSEN, W. Kent, MARTIN, William J
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Cells
Deoxyribonucleic acid
DNA
Drug toxicity and drugs side effects treatment
Lungs
Medical sciences
Pharmacology. Drug treatments
Proteins
Toxicity
Toxicity: respiratory system, ent, stomatology
Online Access:Get full text
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Description
Summary:1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) is an important cause of pulmonary toxicity. BCNU alkylates DNA at the O6 position of guanine.
ISSN:1040-0605
1522-1504