Carbachol-induced actin reorganization involves Gi activation of Rho in human airway smooth muscle cells

To determine whether M2 muscarinic receptors are linked to the monomeric G protein Rho, we studied the effect of carbachol on actin reorganization (stress fiber formation) in cultured human airway smooth muscle cells that expressed mainly M2 muscarinic receptors by dualfluorescence labeling of filam...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 1998-05, Vol.18 (5), p.L803-L809
Main Authors: TOGASHI, H, EMALA, C. W, HALL, I. P, HIRSHMAN, C. A
Format: Article
Language:English
Subjects:
Air breathing
Anatomy & physiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Lungs
Muscular system
Proteins
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Vertebrates: respiratory system
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To determine whether M2 muscarinic receptors are linked to the monomeric G protein Rho, we studied the effect of carbachol on actin reorganization (stress fiber formation) in cultured human airway smooth muscle cells that expressed mainly M2 muscarinic receptors by dualfluorescence labeling of filamentous (F) and monomeric (G) actin.
ISSN:1040-0605
1522-1504