Cell-specific differences in ET-1 system in adjacent layers of main pulmonary artery. A new source of ET-1

Endothelin-1 (ET-1) is a potent vasoconstrictor that causes sustained constriction of the pulmonary artery and modulates normal vascular tone. Endothelial cells were thought to be the major source of ET-1, but recent studies show that vascular smooth muscle cells (SMCs) are also capable of its synth...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2000-04, Vol.22 (4), p.L813-L821
Main Authors: TCHEKNEVA, E, LAWRENCE, M. L, MEYRICK, B
Format: Article
Language:English
Subjects:
Air breathing
Anatomy & physiology
Biological and medical sciences
Blood vessels
Enzymes
Fundamental and applied biological sciences. Psychology
Lungs
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Vertebrates: respiratory system
Online Access:Get full text
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Summary:Endothelin-1 (ET-1) is a potent vasoconstrictor that causes sustained constriction of the pulmonary artery and modulates normal vascular tone. Endothelial cells were thought to be the major source of ET-1, but recent studies show that vascular smooth muscle cells (SMCs) are also capable of its synthesis.
ISSN:1040-0605
1522-1504