Lung matrix incorporation of plasma fibronectin reduces vascular permeability in postsurgical bacteremia

Treatment of human pFN (hFN) with N-ethylmaleimide (NEM) blocks its extracellular matrix (ECM) incorporation but not its ability to augment phagocytosis. Resnikoff et al compared the effect of NEM-treated hFN versus normal hFN on lung transvascular protein clearance (TVPC) in postoperative bacteremi...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 1999-10, Vol.21 (4), p.L749-L759
Main Authors: RESNIKOFF, M, BRIEN, T, VINCENT, P. A, ROTUNDO, R. F, LEWIS, E, MCKEOWN-LONGO, P. J, SABA, T. M
Format: Article
Language:English
Subjects:
Bacteria
Bacterial diseases
Biological and medical sciences
Cellular biology
Experimental bacterial diseases and models
Infectious diseases
Lungs
Medical sciences
Plasma
Sheep
Surgery
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Summary:Treatment of human pFN (hFN) with N-ethylmaleimide (NEM) blocks its extracellular matrix (ECM) incorporation but not its ability to augment phagocytosis. Resnikoff et al compared the effect of NEM-treated hFN versus normal hFN on lung transvascular protein clearance (TVPC) in postoperative bacteremic sheep to determine whether the ability of hFN to attenuate the increase in lung endothelial permeability required its ECM incorporation.
ISSN:1040-0605
1522-1504