Early expression of β- and γ-subunits of epithelial sodium channel during human airway development

The amiloride-sensitive epithelial Na+ channel (ENaC) is an apical membrane protein complex involved in active Na+ absorption and in control of fluid composition in airways. There are no data reporting the distribution of its pore-forming alpha-, beta-, and gamma-subunits in the developing human lun...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2000, Vol.22 (1), p.L177-L184
Main Authors: GAILLARD, D, HINNRASKY, J, COSCOY, S, HOFMAN, P, MATTHAY, M. A, PUCHELLE, E, BARBRY, P
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cells
Child development
Embryology: invertebrates and vertebrates. Teratology
Fetuses
Fundamental and applied biological sciences. Psychology
Lungs
Organogenesis. Fetal development
Organogenesis. Physiological fonctions
Respiratory system
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Summary:The amiloride-sensitive epithelial Na+ channel (ENaC) is an apical membrane protein complex involved in active Na+ absorption and in control of fluid composition in airways. There are no data reporting the distribution of its pore-forming alpha-, beta-, and gamma-subunits in the developing human lung. With use of two different rabbit polyclonal antisera raised against beta- and gamma-ENaC, immunohistochemical localization of the channel was performed in fetal and in adult human airways.
ISSN:1040-0605
1522-1504