IGFBP-3 mediates TGF-beta1-induced cell growth in human airway smooth muscle cells

Both insulin-like growth factor binding protein-3 (IGFBP-3) and transforming growth factor-beta (TGF-beta) have been separately shown to have cell-specific growth-inhibiting or growth-potentiating effects. (TGF-beta) stimulates IGFBP-3 mRNA and peptide expression in several cell types, and TGF-beta-...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2000-03, Vol.22 (3), p.L545
Main Authors: Cohen, Pinchas, Rajah, Roopmathy, Rosenbloom, Joel, Herrick, David J
Format: Article
Language:English
Subjects:
Cells
Insulin
Pediatrics
Proteins
Respiratory system
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Summary:Both insulin-like growth factor binding protein-3 (IGFBP-3) and transforming growth factor-beta (TGF-beta) have been separately shown to have cell-specific growth-inhibiting or growth-potentiating effects. (TGF-beta) stimulates IGFBP-3 mRNA and peptide expression in several cell types, and TGF-beta-induced growth inhibition and apoptosis have been shown to be mediated through the induction of IGFBP-3.
ISSN:1040-0605
1522-1504