Liposomal NAD+ prevents diminished O2 consumption by immunostimulated Caco-2 cells

Research results are consistent with the view that enterocytes exposed to proinflammatory cytokines consume less oxygen due to NAD+/NADH depletion secondary to activation of the nuclear enzyme poly-(ADP-ribose) polymerase by ONOO- or other oxidants.

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2002-05, Vol.26 (5), p.L1082-L1091
Main Authors: KHAN, Abrar U, DELUDE, Russell L, HAN, Yong Y, SAPPINGTON, Penny L, XIANONAN HAN, CARCILLO, Joseph A, FINK, Mitchell P
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cytokines
Digestive system
Enzymes
Fundamental and applied biological sciences. Psychology
Intestine. Mesentery
Oxygen
Vertebrates: digestive system
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Description
Summary:Research results are consistent with the view that enterocytes exposed to proinflammatory cytokines consume less oxygen due to NAD+/NADH depletion secondary to activation of the nuclear enzyme poly-(ADP-ribose) polymerase by ONOO- or other oxidants.
ISSN:1040-0605
1522-1504