PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase

Platelet-derived growth factor (PDGF)-BB has been shown previously to increase glycosaminoglycan (GAG) synthesis but not DNA synthesis in freshly isolated fetal lung fibroblasts. In the present study, we found that PDGF-BB also enhanced 35SO4 incorporation into the small, soluble proteoglycan biglyc...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 1998-05, Vol.18 (5), p.L702-L713
Main Authors: LIU, J, FITZLI, D, MINGYAO LIU, TSEU, I, CANIGGIA, I, ROTIN, D, POST, M
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Cell physiology
Enzymes
Fundamental and applied biological sciences. Psychology
Lungs
Molecular and cellular biology
Peptides
Responses to growth factors, tumor promotors, other factors
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Summary:Platelet-derived growth factor (PDGF)-BB has been shown previously to increase glycosaminoglycan (GAG) synthesis but not DNA synthesis in freshly isolated fetal lung fibroblasts. In the present study, we found that PDGF-BB also enhanced 35SO4 incorporation into the small, soluble proteoglycan biglycan without affecting biglycan's core protein mRNA expression, suggesting that PDGF-BB mainly affects GAG chain elongation and/or sulfation.
ISSN:1040-0605
1522-1504