PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase

Platelet-derived growth factor (PDGF)-BB has been shown previously to increase glycosaminoglycan (GAG) synthesis but not DNA synthesis in freshly isolated fetal lung fibroblasts. In the present study, we found that PDGF-BB also enhanced 35SO4 incorporation into the small, soluble proteoglycan biglyc...

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Published in:American journal of physiology. Lung cellular and molecular physiology 1998-05, Vol.18 (5), p.L702-L713
Main Authors: LIU, J, FITZLI, D, MINGYAO LIU, TSEU, I, CANIGGIA, I, ROTIN, D, POST, M
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Cell physiology
Enzymes
Fundamental and applied biological sciences. Psychology
Lungs
Molecular and cellular biology
Peptides
Responses to growth factors, tumor promotors, other factors
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container_end_page L713
container_issue 5
container_start_page L702
container_title American journal of physiology. Lung cellular and molecular physiology
container_volume 18
creator LIU, J
FITZLI, D
MINGYAO LIU
TSEU, I
CANIGGIA, I
ROTIN, D
POST, M
description Platelet-derived growth factor (PDGF)-BB has been shown previously to increase glycosaminoglycan (GAG) synthesis but not DNA synthesis in freshly isolated fetal lung fibroblasts. In the present study, we found that PDGF-BB also enhanced 35SO4 incorporation into the small, soluble proteoglycan biglycan without affecting biglycan's core protein mRNA expression, suggesting that PDGF-BB mainly affects GAG chain elongation and/or sulfation.
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source American Physiological Society Free
subjects Anatomy & physiology
Biological and medical sciences
Cell physiology
Enzymes
Fundamental and applied biological sciences. Psychology
Lungs
Molecular and cellular biology
Peptides
Responses to growth factors, tumor promotors, other factors
title PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase
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