Airway epithelial Fas ligand expression : potential role in modulating bronchial inflammation

Epithelium-derived Fas ligand is believed to modulate inflammation within various tissues. In this paper, we report findings that suggest a similar immunoregulatory role for Fas ligand in the lung. First, Fas ligand was localized to nonciliated, cuboidal airway epithelial cells (Clara cells) through...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 1998-03, Vol.18 (3), p.L444-L449
Main Authors: GOCHUICO, B. R, MIRANDA, K. M, HESSEL, E. M, DE BIE, J. J, VAN OOSTERHOUT, A. J. M, CRUIKSHANK, W. W, FINE, A
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Cell physiology
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Respiratory diseases
Respiratory system
Signal transduction
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epithelium-derived Fas ligand is believed to modulate inflammation within various tissues. In this paper, we report findings that suggest a similar immunoregulatory role for Fas ligand in the lung. First, Fas ligand was localized to nonciliated, cuboidal airway epithelial cells (Clara cells) throughout the airways in the normal murine lung by employing nonisotopic: in situ hybridization and immunohistochemistry.
ISSN:1040-0605
1522-1504