TGF-beta1 and fibroblast growth factor-1 modify fibroblast growth factor-2 production in type II cells

Fibroblast growth factor (FGF)-2, which stimulates DNA synthesis by type II cells in the lung, has been shown to be regulated by transforming growth factor (TGF)-beta1, an important inflammatory cytokine, in vascular epithelium. The goal of this study was to determine if FGF-2 production by alveolar...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2000-12, Vol.23 (6), p.L1038
Main Authors: Cheng-Ming, Li, Khosla, Jody, Pagan, Ines, Hoyle, Paul, Sannes, Philip L
Format: Article
Language:English
Subjects:
Cells
Deoxyribonucleic acid
DNA
Lungs
Online Access:Get full text
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Summary:Fibroblast growth factor (FGF)-2, which stimulates DNA synthesis by type II cells in the lung, has been shown to be regulated by transforming growth factor (TGF)-beta1, an important inflammatory cytokine, in vascular epithelium. The goal of this study was to determine if FGF-2 production by alveolar type II cells is modulated by TGF-beta1 or FGF-1, which also stimulates DNA synthesis by type II cells.
ISSN:1040-0605
1522-1504