p38 MAP kinase regulates IL-1beta responses in cultured airway smooth muscle cells

Laporte et al investigated whether p38 mitogen-activated protein (MAP) kinase is involved in the Beta-adrenergic hyporesponsiveness in cultured human airway smooth muscle cells due to interleukin (IL)-1Beta. The results confirm the hypothesis that p38 is involved in the signal transduction pathway t...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2000-11, Vol.23 (5), p.L932
Main Authors: Laporte, Johanne D, Moore, Paul E, Lahiri, Thomas, Schwartzman, Igor N
Format: Article
Language:English
Subjects:
Cells
Muscular system
Proteins
Respiratory system
Online Access:Get full text
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Summary:Laporte et al investigated whether p38 mitogen-activated protein (MAP) kinase is involved in the Beta-adrenergic hyporesponsiveness in cultured human airway smooth muscle cells due to interleukin (IL)-1Beta. The results confirm the hypothesis that p38 is involved in the signal transduction pathway through which IL-1Beta induces cyclooxygenase expression, PGE2 release and Beta-adrenergic hyporesponsiveness.
ISSN:1040-0605
1522-1504