Intrinsic ICAM-1/LFA-1 activation mediates altered responsiveness of atopic asthmatic airway smooth muscle

Cell adhesion molecules (CAMs) have been importantly implicated in the pathobiology of the airway responses in allergic asthma, including inflmmatory cell recruitment into the lungs and altered bronchial responsiveness. Collectively, these observations provide new evidence demonstrating that activat...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2000-06, Vol.22 (6), p.L1154-L1163
Main Authors: GRUNSTEIN, M. M, HAKONARSON, H, MASKERI, N, KIM, C, SING CHUANG
Format: Article
Language:English
Subjects:
Asthma
Biological and medical sciences
Cells
Chronic obstructive pulmonary disease, asthma
Medical sciences
Pneumology
Respiratory system
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cell adhesion molecules (CAMs) have been importantly implicated in the pathobiology of the airway responses in allergic asthma, including inflmmatory cell recruitment into the lungs and altered bronchial responsiveness. Collectively, these observations provide new evidence demonstrating that activation of the CAM counterreceptor ligands ICAM-1 and LFA-1, both of which are endogenously expressed in ASM cells, elicits autologously upregulated IL-5 release and associated changes in ICAM-1 expression and agonist responsiveness in atopic asthmatic sensitized ASM.
ISSN:1040-0605
1522-1504