Effect of erythromycin on ATP-induced intracellular calcium response in A549 cells

ATP induced a biphasic increase in the intracellular Ca2+ concentration ([Ca2+]i), an initial spike, and a subsequent plateau in A549 cells, Erythromycin (EM) suppressed the ATP-induced [Ca2+]i spike but only in the presence of extracellular calcium (Ca02+).

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2000-04, Vol.22 (4), p.L726-L736
Main Authors: ZHAO, D.-M, XUE, H.-H, CHIDA, K, SUDA, T, OKI, Y, KANAI, M, UCHIDA, C, ICHIYAMA, A, NAKAMURA, H
Format: Article
Language:English
Subjects:
Anatomy & physiology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
ATP
Biological and medical sciences
Calcium
Cells
Lungs
Medical sciences
Pharmacology. Drug treatments
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Description
Summary:ATP induced a biphasic increase in the intracellular Ca2+ concentration ([Ca2+]i), an initial spike, and a subsequent plateau in A549 cells, Erythromycin (EM) suppressed the ATP-induced [Ca2+]i spike but only in the presence of extracellular calcium (Ca02+).
ISSN:1040-0605
1522-1504