Hyperoxia synergistically increases TNF-α-induced interleukin-8 gene expression in A549 cells

Interleukin (IL)-8 is an important mediator of acute lung injury. Hyperoxia induces IL-8 production in some cell types, but its effect on IL-8 gene expression in respiratory epithelium is not well described.

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2000-02, Vol.22 (2), p.L253-L260
Main Authors: ALLEN, G. L, MENENDEZ, I. Y, RYAN, M. A, MAZOR, R. L, WISPE, J. R, FIEDLER, M. A, WONG, H. R
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Cellular biology
Emergency and intensive respiratory care
Genes
Intensive care medicine
Lungs
Medical sciences
Oxygen
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Description
Summary:Interleukin (IL)-8 is an important mediator of acute lung injury. Hyperoxia induces IL-8 production in some cell types, but its effect on IL-8 gene expression in respiratory epithelium is not well described.
ISSN:1040-0605
1522-1504