Mechanism of all trans-retinoic acid and glucocorticoid regulation of sufactant protein mRNA

The surfactant proteins (SPs) are required for the normal function of pulmonary surfactant, a lipoprotein substance that prevents alveolar collapse at end expiration. We characterized the effects of cortisol and all trans-retinoic acid (RA) on SP-A and SP-B gene expression in H441 cells, a human pul...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 1998-04, Vol.18 (4), p.L560
Main Authors: George, Thomas N, Miakotina, Olga L, Goss, Kelli L, Synder, Jeanne M
Format: Article
Language:English
Subjects:
Anatomy & physiology
Lungs
Proteins
Ribonucleic acid
RNA
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Summary:The surfactant proteins (SPs) are required for the normal function of pulmonary surfactant, a lipoprotein substance that prevents alveolar collapse at end expiration. We characterized the effects of cortisol and all trans-retinoic acid (RA) on SP-A and SP-B gene expression in H441 cells, a human pulmonary adenocarcinoma cell line. Cortisol, at 10-6 M, caused a significant inhibition of SP-A mRNA to levels that were 60-70% of controls and a five- to sixfold increase in the levels of SP-B mRNA.
ISSN:1040-0605
1522-1504