G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease

Several cystic fibrosis (CF) mouse models demonstrate an increased susceptibility to Pseudomonas aeruginosa lung infection, characterized by excessive inflammation and high rates of mortality. Here we developed a model of chronic P. aeruginosa lung disease in mice homozygous for the murine CF transm...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2001-09, Vol.25 (3), p.L740-L747
Main Authors: MCMORRAN, B. J, PALMER, J. S, LUNN, D. P, OCEANDY, D, COSTELLOE, E. O, THOMAS, G. R, HUME, D. A, WAINWRIGHT, B. J
Format: Article
Language:English
Subjects:
Bacteria
Bacterial diseases
Biological and medical sciences
Cellular biology
Cystic fibrosis
Disease
Experimental bacterial diseases and models
Gastroenterology. Liver. Pancreas. Abdomen
Infectious diseases
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Lungs
Medical sciences
Other diseases. Semiology
Rodents
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Summary:Several cystic fibrosis (CF) mouse models demonstrate an increased susceptibility to Pseudomonas aeruginosa lung infection, characterized by excessive inflammation and high rates of mortality. Here we developed a model of chronic P. aeruginosa lung disease in mice homozygous for the murine CF transmembrane conductance regulator G551D mutation that provides an excellent model for CF lung disease.
ISSN:1040-0605
1522-1504