Prostaglandin E2 inhibits fibroblast chemotaxis

Fibroblasts are the major source of extracellular connective tissue matrix, and the recruitment, accumulation, and stimulation of these cells are thought to play important roles in both normal healing and the development of fibrosis. Prostaglandin E2 (PGE2) can inhibit this process by blocking fibro...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2001-11, Vol.25 (5), p.L1257-L1263
Main Authors: KOHYAMA, Tadashi, ERTL, Ronald F, VALENTI, Vincenzo, SPURZEM, John, KAWAMOTO, Masashi, NAKAMURA, Yoichi, VEYS, Tom, ALLEGRA, Luigi, ROMBERGER, Debra, RENNARD, Stephen I
Format: Article
Language:English
Subjects:
Air breathing
Biological and medical sciences
Cellular biology
Fundamental and applied biological sciences. Psychology
Lungs
Molecules
Respiratory diseases
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Tissues
Vertebrates: respiratory system
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Summary:Fibroblasts are the major source of extracellular connective tissue matrix, and the recruitment, accumulation, and stimulation of these cells are thought to play important roles in both normal healing and the development of fibrosis. Prostaglandin E2 (PGE2) can inhibit this process by blocking fibroblast proliferation and collagen production.
ISSN:1040-0605
1522-1504