Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components

Commercial baicalein (α form) exhibits deficient tabletability. Cocrystals of baicalein with nicotinamide, caffeine, and isoniazid were all shown to display excellent tabletability, despite the three coformers having high, medium, and poor tabletability, respectively. A crystal structure analysis us...

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Bibliographic Details
Published in:CrystEngComm 2018, Vol.20 (37), p.5486-5489
Main Authors: Liu, Lili, Wang, Chenguang, Dun, Jiangnan, Chow, Albert H. L., Sun, Changquan Calvin
Format: Article
Language:English
Subjects:
Caffeine
Crystal structure
Crystallography
Dependence
Mechanical properties
Nicotinamide
Structural analysis
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Summary:Commercial baicalein (α form) exhibits deficient tabletability. Cocrystals of baicalein with nicotinamide, caffeine, and isoniazid were all shown to display excellent tabletability, despite the three coformers having high, medium, and poor tabletability, respectively. A crystal structure analysis using the energy framework approach revealed that the superior tabletability of these cocrystals always correlated with structural features rendering high plasticity irrespective of the coformer involved.
ISSN:1466-8033
1466-8033
DOI:10.1039/C8CE00787J