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Embryonic effects of an environmentally relevant PCB mixture in the domestic chicken

Studies were conducted to develop methods to assess the effects of a complex mixture of polychlorinated biphenyls (PCBs) in the domestic chicken (Gallus domesticus). Treatments were administered by egg injection to compare embryonic effects of an environmentally relevant PCB congener mixture in the...

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Bibliographic Details
Published in:Environmental toxicology and chemistry 2018-10, Vol.37 (10), p.2513-2522
Main Authors: Ottinger, Mary Ann, Lavoie, Emma T., Bohannon, Meredith E.B., Marcel, Allegra M., Tschiffely, Anna E., Duffy, Kara B., McKernan, Moira, Thompson, Nichola, Whitehouse, H. Kasen, Davani, Kimya, Strauss, Marci, Tillitt, Donald E., Lipton, Josh, Dean, Karen M.
Format: Article
Language:English
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Summary:Studies were conducted to develop methods to assess the effects of a complex mixture of polychlorinated biphenyls (PCBs) in the domestic chicken (Gallus domesticus). Treatments were administered by egg injection to compare embryonic effects of an environmentally relevant PCB congener mixture in the domestic chicken over a range of doses. Chicken eggs were injected with the PCB mixture with a profile similar to that found in avian eggs collected on the upper Hudson River, New York, USA, at doses that spanned 0 to 98 μg/g egg. Eggs were hatched in the laboratory to ascertain hatching success. In the domestic chicken, the median lethal dose was 0.3 μg/g. These data demonstrate adverse effects of an environmentally relevant PCB mixture and provide the basis for further work using in vitro and other models to characterize the potential risk to avian populations. Environ Toxicol Chem 2018;37:2513–2522. © 2018 SETAC
ISSN:0730-7268
1552-8618
DOI:10.1002/etc.4218