Bioactive coatings on porous titanium for biomedical applications

Commercial pure titanium is a recognized and accepted material for cortical bone tissue substitution. However, stress-shielding phenomena and lack of osseointegration result in significant limitations. This work is focused on the achievement of an effective solution for both problems via fabrication...

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Bibliographic Details
Published in:Surface & coatings technology 2018-09, Vol.349, p.584-592
Main Authors: Domínguez-Trujillo, C., Ternero, F., Rodríguez-Ortiz, J.A., Heise, S., Boccaccini, A.R., Lebrato, J., Torres, Y.
Format: Article
Language:English
Subjects:
Bioactive glass coating
Biocompatibility
Bioglass
Biological activity
Biomedical materials
Body fluids
Chemical composition
Chipping
Compression tests
Glass substrates
Hydroxyapatite
In vitro bioactivity
In vitro methods and tests
Infiltration
Mechanical properties
Mechanical tests
Organic chemistry
Osseointegration
Porosity
Porous titanium
Protective coatings
Sedimentation
Stiffness
Stress shielding
Stress-strain curves
Structural integrity
Surgical implants
Titanium
Ultrasonic testing
Ultrasound
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Summary:Commercial pure titanium is a recognized and accepted material for cortical bone tissue substitution. However, stress-shielding phenomena and lack of osseointegration result in significant limitations. This work is focused on the achievement of an effective solution for both problems via fabrication of porous titanium substrates coated with bioactive glass. Substrates were obtained through the space holder technique giving values of stiffness and yield strength compatible with cortical bone tissue to reduce the stress-shielding phenomenon. Titanium substrates were coated with different number of layers of bioactive glass 45S5 by dripping sedimentation. The substrates porosity was characterized by different techniques. Ultrasound, compression and micro-mechanical testing were used for mechanical properties evaluation. After substrates coating, the infiltration ability, coating homogeneity and structural integrity (chipping and cracking) were evaluated for each coating layer. The chemical composition of coating and phases were studied before and after in vitro tests in Simulated Body Fluid. The results showed more homogenous coating, adherence and greater hydroxyapatite growth for the tri-layer system in both dense and porous samples. Besides, the relation of Ca/P was closed to that of stoichiometric hydroxyapatite in the human body. The coated porous titanium could be potentially used in load bearing partial implants with improved osseointegration. [Display omitted] •A new bioactive glass deposition technique is implemented to improve the osseointegration.•Hydroxiapatite formation is confirmed by in vitro test despite the bioactive glass coating crystallization.•The coated titanium samples have a biomechanical and biofunctional equilibrium.•Better adhesion of the coating on porous titanium substrates than on full dense ones
ISSN:0257-8972
1879-3347
DOI:10.1016/j.surfcoat.2018.06.037