In vitro solubility of 7Be particles released from a damaged source

The solubility of 7 Be particles was measured in vitro as part of an evaluation of the exposure of workers who inhaled particles released from a damaged source. Initial in vivo measurements performed with one worker revealed that a significant fraction of 7 Be particles were rapidly removed from the...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2018, Vol.318 (1), p.753-759
Main Authors: Aviv, O., Sasson, R., Spitz, H. B., Halfon, S., Maugeri, E. A., Yungrais, Z., Daniely, E., Koch, J.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Damage
Diagnostic Radiology
Hadrons
Heavy Ions
Inorganic Chemistry
Nuclear Chemistry
Nuclear Physics
Physical Chemistry
Solubility
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Summary:The solubility of 7 Be particles was measured in vitro as part of an evaluation of the exposure of workers who inhaled particles released from a damaged source. Initial in vivo measurements performed with one worker revealed that a significant fraction of 7 Be particles were rapidly removed from the respiratory tract with a half-life of approximately 0.4 days. Since rapid clearance of 7 Be was not supported by conventional biokinetic models, a study of the solubility of the particles in vitro was launched. A representative sample of the 7 Be particles was collected from the damaged source and exposed to a surrogate lung fluid solution for increasing periods of time. Over 98% of the material was dissolved at the end of the dissolution period. The effective half-time for solubility of the majority of 7 Be particles was found to be ≅ 0.4 days and is wholly consistent with results of in vivo measurements.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-018-6109-5