Cationic lipid binding control in DNA based biopolymer and its impacts on optical and thermo-optic properties of thin solid films

Biomaterials based on deoxyribonucleic acid (DNA) have shown notable potential in optoelectronic and photonic devices. In order to further investigate the optical properties of a DNA-based lipid complex such as DNA-cetyltrimethylammonium (CTMA), which is widely used in current DNA thin film research...

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Bibliographic Details
Published in:Optical materials express 2017-11, Vol.7 (11), p.3796
Main Authors: Jung, Woohyun, Jun, Hwiseok, Hong, Seongjin, Paulson, Bjorn, Nam, Yoon Sung, Oh, Kyunghwan
Format: Article
Language:English
Subjects:
Binding
Biomedical materials
Biopolymers
Deoxyribonucleic acid
DNA
Lipids
Moisture content
Optical measurement
Optical properties
Optics
Optoelectronic devices
Photonics
Precipitates
Refractivity
Silicon substrates
Spectrometry
Spin coating
Thermodynamic properties
Thin films
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Summary:Biomaterials based on deoxyribonucleic acid (DNA) have shown notable potential in optoelectronic and photonic devices. In order to further investigate the optical properties of a DNA-based lipid complex such as DNA-cetyltrimethylammonium (CTMA), which is widely used in current DNA thin film research, a new refinement process was developed to minimize the relative bound water content and control binding of CTMA onto the DNA backbone. The water contents and CTMA binding in the DNA-CTMA precipitates were identified by spectrometric measurements to quantify effects of our refinement process. Dissolving these refined DNA-CTMAs in organic solvents, thin solid films were deposited on Si and quartz substrate using the spin coating process. Their refractive indices and absorbance were measured to quantitatively assess the impact of our refinement process on the optical properties of the DNA-CTMA films. In addition, thermo-optic coefficients, dn/dT, were also measured in a temperature range from 30 to 100°C to observe differences among refined DNA-CTMAs. Detailed quantitative spectroscopic analyses and optical measurements are reported.
ISSN:2159-3930
2159-3930
DOI:10.1364/OME.7.003796