The Acute Post-Traumatic Period in Rats Is Accompanied by an Anxiety State and a Decrease in the Proportion of REM Sleep

The sequelae of craniocerebral trauma (CCT) were studied using a model based on severe (3–4 atm) lateral hydrodynamic percussion (liquid-percussive brain injury) in male Sprague–Dawley rats. With the aim of detecting the symptoms of anxiety states, the rats’ behavior was assessed in the dark-light b...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience and behavioral physiology 2018-09, Vol.48 (7), p.785-795
Main Authors: Komol’tsev, I. G., Levshina, I. P., Novikova, M. R., Tishkina, A. O., Stepanichev, M. Yu, Gulyaeva, N. V.
Format: Article
Language:English
Subjects:
Anxiety
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Brain injury
Complications
Neurobiology
Neurosciences
Percussion
Post traumatic stress disorder
Rats
REM sleep
Sleep
Trauma
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The sequelae of craniocerebral trauma (CCT) were studied using a model based on severe (3–4 atm) lateral hydrodynamic percussion (liquid-percussive brain injury) in male Sprague–Dawley rats. With the aim of detecting the symptoms of anxiety states, the rats’ behavior was assessed in the dark-light box and the elevated plus maze test; sleep impairments were detected by recording the electrocorticogram (ECoG) before trauma and during the first week after trauma. The results provided evidence of the post-CCT development of signs of an anxiety state, accompanied by decreases in the proportion of REM sleep and decreases in the amplitude and frequency of the ECoG during this phase.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-018-0631-3