Male–Female Differences in the Prevalence of Non-Hodgkin Lymphoma and Residential Proximity to Superfund Sites in Kentucky

Non-Hodgkin lymphoma (NHL) is a category of cancers that arise from lymphocytes. Previous work by the authors demonstrated a significant association between residential proximity to Superfund sites in Kentucky and cumulative incidence rates of NHL. In both the U.S. and Kentucky, age-adjusted NHL rat...

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Published in:Journal of environmental health 2018-10, Vol.81 (3), p.16-25
Main Authors: Stone, Ramona, Webber, W. Brent
Format: Article
Language:English
Subjects:
ADVANCEMENT OF THE SCIENCE
Age
Autoimmune diseases
Body mass index
Buffer zones
Cancer
Cancer therapies
Cytokines
Demographic aspects
Environmental cleanup
Environmental protection
Epidemiology
Females
Gender differences
Hazardous waste sites
Health aspects
Incidence
Leukemia
Life span
Lymphocytes
Lymphoma
Males
Melanoma
Non-Hodgkin's lymphomas
Pollution abatement
Prevalence studies (Epidemiology)
Proximity
Public health
Regression analysis
Risk factors
Sex differences
Statistics
Superfund
Toxicants
Womens health
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Webber, W. Brent
description Non-Hodgkin lymphoma (NHL) is a category of cancers that arise from lymphocytes. Previous work by the authors demonstrated a significant association between residential proximity to Superfund sites in Kentucky and cumulative incidence rates of NHL. In both the U.S. and Kentucky, age-adjusted NHL rates in males consistently exceed rates in females, despite NHL often arising later in the lifespan when females outnumber males. The current investigation sought to determine whether the NHL rate difference by sex is associated with proximity to environmental toxicants. Cancer data for a period of 18 years were obtained from the Kentucky Cancer Registry. Superfund geospatial coordinate data were obtained from the U.S. Environmental Protection Agency. Cumulative incidence rates per 100,000 males and females were calculated at the 2010 U.S. Census Bureau tract level, within
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Brent</creator><creatorcontrib>Stone, Ramona ; Webber, W. Brent</creatorcontrib><description>Non-Hodgkin lymphoma (NHL) is a category of cancers that arise from lymphocytes. Previous work by the authors demonstrated a significant association between residential proximity to Superfund sites in Kentucky and cumulative incidence rates of NHL. In both the U.S. and Kentucky, age-adjusted NHL rates in males consistently exceed rates in females, despite NHL often arising later in the lifespan when females outnumber males. The current investigation sought to determine whether the NHL rate difference by sex is associated with proximity to environmental toxicants. Cancer data for a period of 18 years were obtained from the Kentucky Cancer Registry. Superfund geospatial coordinate data were obtained from the U.S. Environmental Protection Agency. Cumulative incidence rates per 100,000 males and females were calculated at the 2010 U.S. Census Bureau tract level, within &lt;5 km and 5–10 km buffer zones around Superfund sites. Ordinary least squares and geographically weighted regression analyses were conducted. Significant associations existed between residential proximity to Superfund sites and cumulative NHL incidence rates in male and female populations. At all exposures levels, incidence rates were significantly higher for males than females. 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The current investigation sought to determine whether the NHL rate difference by sex is associated with proximity to environmental toxicants. Cancer data for a period of 18 years were obtained from the Kentucky Cancer Registry. Superfund geospatial coordinate data were obtained from the U.S. Environmental Protection Agency. Cumulative incidence rates per 100,000 males and females were calculated at the 2010 U.S. Census Bureau tract level, within &lt;5 km and 5–10 km buffer zones around Superfund sites. Ordinary least squares and geographically weighted regression analyses were conducted. Significant associations existed between residential proximity to Superfund sites and cumulative NHL incidence rates in male and female populations. At all exposures levels, incidence rates were significantly higher for males than females. Possible reasons for this male–female imbalance in outcomes are presented, along with implications for public health.</abstract><cop>Denver</cop><pub>National Environmental Health Association</pub><tpages>10</tpages></addata></record>
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source JSTOR Archival Journals and Primary Sources Collection
subjects ADVANCEMENT OF THE SCIENCE
Age
Autoimmune diseases
Body mass index
Buffer zones
Cancer
Cancer therapies
Cytokines
Demographic aspects
Environmental cleanup
Environmental protection
Epidemiology
Females
Gender differences
Hazardous waste sites
Health aspects
Incidence
Leukemia
Life span
Lymphocytes
Lymphoma
Males
Melanoma
Non-Hodgkin's lymphomas
Pollution abatement
Prevalence studies (Epidemiology)
Proximity
Public health
Regression analysis
Risk factors
Sex differences
Statistics
Superfund
Toxicants
Womens health
title Male–Female Differences in the Prevalence of Non-Hodgkin Lymphoma and Residential Proximity to Superfund Sites in Kentucky
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