Ethanol via Regulation of NF-κB/p53 Signaling Pathway Increases Manganese-Induced Inflammation and Apoptosis in Hypothalamus of Rats

• Published in: Biological trace element research 2019-07, Vol.190 (1), p.101-108
• Main Authors: Nkpaa, Kpobari W., Adedara, Isaac A., Amadi, Benjamin A., Wegwu, Matthew O., Farombi, Ebenezer O.
• Format: Article
• Language: English
• Subjects: Alcohol use; Alcohols; Antagonism; Apoptosis; Autonomic nervous system; BAX protein; Bcl-2 protein; Biochemistry; Biomarkers; Biomedical and Life Sciences; Biotechnology; Body weight; Caspase; Caspase-3; Cyclooxygenase-2; Cytokines; Drinking behavior; Drinking water; Epidemiology; Ethanol; Exposure; Hypothalamus; Immunohistochemistry; Inflammation; Interleukin 1; Life Sciences; Lymphocytes B; Lymphoma; Manganese; Necrosis; Neoplasms; NF-κB protein; Nutrition; Oncology; Organic chemistry; p53 Protein; Proteins; Rats; Rodents; Signal transduction; Signaling; Synergism; Tumor necrosis factor-TNF; Tumor necrosis factor-α
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-018-1535-3

The diet is a major route of manganese (Mn) exposure for humans. Interestingly, several epidemiological data demonstrated an increase in the incidence of alcohol consumption globally. Chemical-chemical interaction subsequent to chemical mixtures exposure may result in a synergism or antagonism effects. The present study investigated the influence of co-exposure to ethanol (EtOH) and Mn on inflammation and apoptosis in the hypothalamus of rats. The study consisted of five groups of rats that were exposed to drinking water alone, EtOH alone at 5 g/kg, Mn alone at 30 mg/kg or co-expose with EtOH at 1.25 and 5 g/kg body weight by oral gavage for 35 consecutive days. The results indicated that the significant ( p