Synthesis of Sub‐100 nm Glycosylated Nanoparticles via a One Step, Free Radical, and Surfactant Free Emulsion Polymerization

The facile synthesis of sub‐100 nm glyco nanoparticles is presented via a one‐step, free radical, and surfactant free emulsion polymerization. It is shown that by using sterically large, hydrophilic glycomonomers such as a lactose acrylamide with the charged azo initiator 4,4′‐azobis(4‐cyanovaleric...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2018-10, Vol.39 (19), p.e1800122-n/a
Main Authors: Lunn, Andrew M., Perrier, Sébastien
Format: Article
Language:English
Subjects:
Acrylamide
Acrylamide - chemistry
Charged particles
Chemical synthesis
Emulsion polymerization
Emulsions
Free radical polymerization
Free radicals
Glycosylation
glyco‐nanoparticles
Lactose
Lactose - chemistry
Nanoparticles
Nanoparticles - chemistry
Particle Size
Polymerization
surfactant free
Surfactants
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Summary:The facile synthesis of sub‐100 nm glyco nanoparticles is presented via a one‐step, free radical, and surfactant free emulsion polymerization. It is shown that by using sterically large, hydrophilic glycomonomers such as a lactose acrylamide with the charged azo initiator 4,4′‐azobis(4‐cyanovaleric acid), growing particles are stabilized enough to reproducibly produce well defined (PDi ≤ 0.1) glycoparticles with diameters below 100 nm. A rapid one‐step approach to synthesize sub‐100 nm polymeric glyco nanoparticles without the use of a surfactant is presented. The free radical method takes advantage of the exceptional ability of glycomonomers, particularly lactose acrylamide to stabilize a growing latex particle, with the use of the charged initiator 4,4′‐azobis(4‐cyanovaleric acid) to go from monomer to final latex in under 3 h.
ISSN:1022-1336
1521-3927
DOI:10.1002/marc.201800122