GW29-e1854 The receptor-interacting protein 2 (Rip2) is involved in regulation of mouse heart senescence

Unfortunately, current interventions against oxidative stress and inflammation during aging did not bring expected results. [...]it is essential to investigate the pathogenesis of heart aging and find new strategies. Rip2 is a key receptor protein of inflammation pathway, but its role and mechanism...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2018-10, Vol.72 (16), p.C63-C64
Main Authors: Feng, Hong, Liao, Haihan, Tang, Qizhu
Format: Article
Language:English
Subjects:
Aging
Cardiology
Cardiovascular disease
Heart
Inflammation
Mortality
Oxidative stress
Phosphorylation
Proteins
Rodents
Senescence
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Summary:Unfortunately, current interventions against oxidative stress and inflammation during aging did not bring expected results. [...]it is essential to investigate the pathogenesis of heart aging and find new strategies. Rip2 is a key receptor protein of inflammation pathway, but its role and mechanism during cardiac aging has not yet been elucidated.Methods Wild-type mice (WT), Rip-2 knockout mice (Rip2-KO), and Rip-2 cardiac-specific transgenic mice (Rip-cTg) were housed for 2 years. Conversely, deletion of Rip2 can alleviate cardiac senescence through inhibiting activation of aforementioned signaling pathways. [...]specific inhibition of Rip2 activity may improve aging-related heart injuries.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2018.08.231