The Association of Acromegaly and Visfatin

Introduction: Acromegaly is a systemic disease that causes multiple metabolic disorders caused by an excess of growth hormone. The excess of growth hormone affects the secretion of adipokines in fat tissue, leading to metabolic disorders. Visfatin is also an adipokine synthesized in visceral fat tis...

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Published in:Turkish journal of endocrinology and metabolism 2018, Vol.22 (2), p.33-34
Main Authors: PİŞKİNPAŞA, Hamide, OKUTURLAR, Yıldız, ÇİFTÇİ DOĞANŞEN, Sema, AKDENİZ, Yasemin Şefika, ESEN, Ayşe, SADRİ, Sogol, PİRHAN, Osman, ADAŞ, Mine, OCAK SERİN, Sibel, GEDİKBAŞI, Asuman, MERT, Meral
Format: Article
Language:English
Subjects:
Correlation analysis
Growth hormones
Metabolic disorders
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Summary:Introduction: Acromegaly is a systemic disease that causes multiple metabolic disorders caused by an excess of growth hormone. The excess of growth hormone affects the secretion of adipokines in fat tissue, leading to metabolic disorders. Visfatin is also an adipokine synthesized in visceral fat tissue,and plays a role in systemic inflammation. In this study, we evaluated the effect of acromegaly on serum visfatin levels and the parameters that may be associated with it. Method: 53 acromegaly patients (37 females/16 males) in acromaegaly gruop and 34 patient (22 females/12 males) in the control group with normal IGF1 and BH with similar age and body mass index (BMI) were included in our study. The waist and hip circumference, fasting blood glucose, insulin, HbA1c, lipid profile, BH, IGF1 and visfatin levels were compared among the groups. Epicardial fat tissue was examined by echocardiography. Serum visfatin levels were measured by micro ELISA. Correlation analysis was performed. Result: The visfatin levels in the acromegaly group were significantly higher than the control group (p
ISSN:1301-2193
1308-9846
DOI:10.25179/tjem.20182202-P064