Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation

Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly...

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Bibliographic Details
Published in:Case reports in gastroenterology 2018-01, Vol.12 (1), p.76-84
Main Authors: Schneider, Kai Markus, Wirtz, Theresa H., Kroy, Daniela, Albers, Stefanie, Neumann, Ulf Peter, Strowig, Till, Sellge, Gernot, Trautwein, Christian
Format: Article
Language:English
Subjects:
Abdomen
Antibiotics
Bacterial infections
Case and Review
Case reports
Clostridium difficile infection
Diarrhea
Fecal microbiota transplantation
Feces
Infections
Infectious diseases
Inflammatory bowel disease
Liver
Liver transplantation
Liver transplants
Microbiota
Patients
Pseudomembranous colitis
Transplants & implants
Ultrasonic imaging
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Summary:Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use. Additionally, these patients may be especially prone to adverse events related to FMT. Here, we report a successful FMT in a patient with severe therapy-refractory CDI after liver transplantation.
ISSN:1662-0631
1662-0631
DOI:10.1159/000481937