Effect of Cheddar cheese peptide extracts on growth inhibition, cell cycle arrest and apoptosis induction in human lung cancer (H‐1299) cell line

The objective of the study was to evaluate the anticancer activity of water‐soluble peptide (WSP) extracts of buffalo and cow milk Cheddar cheeses during their ripening. The WSP extracts were assessed for their effects on cell viability, cell cycle arrest and apoptosis induction using a lung cancer...

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Bibliographic Details
Published in:International journal of dairy technology 2018-11, Vol.71 (4), p.975-980
Main Authors: Rafiq, Saima, Huma, Nuzhat, Gulzar, Nabila, Murtaza, Mian Anjum, Hussain, Imtiaz
Format: Article
Language:English
Subjects:
Anticancer properties
Antitumor activity
Apoptosis
Apoptosis induction
Cancer
Cell cycle
Cell cycle arrest
Cheddar cheese
Cheese
Cow's milk
Dairy products
Inhibition
Lung cancer
Peptides
Ripening
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Summary:The objective of the study was to evaluate the anticancer activity of water‐soluble peptide (WSP) extracts of buffalo and cow milk Cheddar cheeses during their ripening. The WSP extracts were assessed for their effects on cell viability, cell cycle arrest and apoptosis induction using a lung cancer (H‐1299) cell line. Cheese extracts taken after 120 and 150 ripening days showed marked growth inhibition of the cancer cells, in a dose‐dependent manner. During cell cycle analysis, a significant increase in cells population at G2/M phase was observed in the lung cancer cell line at a rate of 400 μg/mL and 500 μg/mL. In addition, the extracts also induced extensive apoptosis in the lung cancer cell line.
ISSN:1364-727X
1471-0307
DOI:10.1111/1471-0307.12533