Novel Pyrazolo[1,5‐a]Pyrimidines and Pyrazolo[5,1‐c][1,2,4]Triazines Incorporating Indole Moiety as a New Class of Antioxidant Agents

This effort focuses on the construction of novel pyrazolo[1,5‐a]pyrimidines bearing indole nucleus via the reaction of 3‐(1H‐indol‐3‐yl)‐1H‐pyrazol‐5‐amine (3) with the appropriate reagents or through solvent free condensations with active methylene components and triethyl orthoformate. The utility...

Full description

Saved in:
Bibliographic Details
Published in:Journal of heterocyclic chemistry 2018-10, Vol.55 (10), p.2303-2308
Main Authors: El‐Mekabaty, Ahmed, Fadda, Ahmed A.
Format: Article
Language:English
Subjects:
Antioxidants
Coupling (molecular)
Methylene
Pyrimidines
Reagents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This effort focuses on the construction of novel pyrazolo[1,5‐a]pyrimidines bearing indole nucleus via the reaction of 3‐(1H‐indol‐3‐yl)‐1H‐pyrazol‐5‐amine (3) with the appropriate reagents or through solvent free condensations with active methylene components and triethyl orthoformate. The utility of (3) for the preparation of pyrazolo[5,1‐c][1, 2, 4]triazines was also explored via coupling of diazonium salt of (3) with active methylene compounds. Antioxidant activity screening of the synthetic targets showed that compounds (13), (14), (16), and (17) exhibited a promising activity.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3288