Molecular Docking Studies of 3-A-Carboxy Ethyl Rhodanine and 3-A-Carboxy Methyl Rhodanine against T315i BCR-ABL and HPV 16

Many chemotherapeutic agents are currently available in the market used for treatment of cancer, but the disease is still remains dangerous [3]. [...]the search of new methods for novel anticancer agents with high efficacy, minimum side effects and low toxicity is a more active research area [4-5]....

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2018-08, Vol.10 (8), p.2069-2073
Main Authors: Kumar, Rajendran, Celestina, Stephen Kumar, Sundaram, Kaveri, Ravi, Subban
Format: Article
Language:English
Subjects:
Cancer
Hydrogen
Ligands
Proteins
Studies
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Summary:Many chemotherapeutic agents are currently available in the market used for treatment of cancer, but the disease is still remains dangerous [3]. [...]the search of new methods for novel anticancer agents with high efficacy, minimum side effects and low toxicity is a more active research area [4-5]. Rhodanine is a heterocyclic compound and it is used as a scaffold for the development of novel anticancer agents with wide range of cytotoxicity against many human cancer cells [7]. RESULT AND DISCUSSION Molecular docking study against target proteins T3151 Abl mutant protein (PDB ID: 2V7A) and HPV 16 (PDB ID: 1DTO) involved in anticancer mechanisms was carried out for 32 compounds to see the binding affinity of the ligands and the receptor.
ISSN:0975-1459