The effects of tomato (Lycopersicon esculentum) extract on carbimazole-induced biochemical alter-ations in pancreas of albino rats

Acute pancreatitis is a relatively common disease with an estimated annual mortality rate of about 7%. Drug-use is a major etiological factor in the pathogenesis and pathophysiology of the condition. The aim of this study was to evaluate the effects of tomato extract on carbimazoleinduced biochemica...

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Bibliographic Details
Published in:Journal of medical and allied sciences 2018-01, Vol.8 (2), p.59-65
Main Authors: Uchendu, Ikenna Kingsley, Agu, Chidozie Elochukwu, Orji, Oliver Chukwuma
Format: Article
Language:English
Subjects:
Albinism
Alcoholism
Analgesics
Antioxidants
Bioavailability
Biochemistry
Flavonoids
Food products
Free radicals
Fruits
Gallstones
Investigations
Mortality
Pancreas
Pancreatitis
Pathogenesis
Phytochemicals
Substance abuse treatment
Triglycerides
Vitamin C
Vitamin E
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Summary:Acute pancreatitis is a relatively common disease with an estimated annual mortality rate of about 7%. Drug-use is a major etiological factor in the pathogenesis and pathophysiology of the condition. The aim of this study was to evaluate the effects of tomato extract on carbimazoleinduced biochemical alterations in the pancreas of albino rats. phytochemical analysis of the tomato extract was done. A total of 24 male albino wistar rats weighing (225±25g) were randomly divided into 4 groups (A-D) with six rats per group. Group A served as the normal control group and received no treatment. Group B received only carbimazole (60mg/kg, oral) and served as the negative control group. Group C received vitamin C (200mg/kg, oral) and served as the positive control and Group D which served as test group received tomato extract (30mg/kg, oral) in the presence of carbimazole challenge for 4 weeks. Carbimazole administration to rats resulted in pancreatic damage with glucose, amylase, triglycerides and total protein levels: 126.33±6.64 mg/dl; 484.00±18.33 IU/L; 0.75±0.09 mmol/l and 4.83±0.12 g/dl respectively. The daily administration of tomato extract resulted in the mitigation of the carbimazole-induced pancreatic damage with glucose, amylase, triglyceride and total protein levels: 106.33±296 mg/dl (p0.05) respectively. Tomato (Lycopersicon esculentum) possesses pancreas-protective property against carbimazole- induced pancreatic damage.
ISSN:2231-1696
2231-170X
DOI:10.5455/jmas.285861