Infertility. The acrosome index, radical buffer capacity and number of isolated progressively motile spermatozoa predict IVF results

BACKGROUND: The accuracy by which a number of newly described semen variables can predict either total fertilization failure (TFF) or pregnancy outcome in IVF, has not previously been investigated. The study aim was, therefore, to determine prospectively the predictive value of these variables. METH...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2001-09, Vol.16 (9), p.1885
Main Authors: Johann P.T. Rhemrev, Menkveld, Roelof, Roseboom, Tessa J, Floris W.P.C. van Overveld, Teerlink, Tom, Lombard, Carl, Jan P.W. Vermeiden
Format: Article
Language:English
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Summary:BACKGROUND: The accuracy by which a number of newly described semen variables can predict either total fertilization failure (TFF) or pregnancy outcome in IVF, has not previously been investigated. The study aim was, therefore, to determine prospectively the predictive value of these variables. METHODS: The semen variables investigated were the post-wash total progressively motile sperm cell count (TPMCpost-wash), the acrosome index (AI), `cytoplasmic residues' and normal sperm morphology, evaluated according to the strict criteria (`strict criteria'), as well as the fast and slow total radical trapping antioxidant potential (`fast TRAP' and `slow TRAP' respectively). RESULTS: The study group (n = 87) showed a mean (+ or - SD) number of 10.2 + or - SD retrieved oocytes, 12.6% TFF, a mean fertilization rate of 59.7% and a pregnancy rate of 19.5% (17/87). TFF was significantly predicted by TPMCpost-wash, `strict criteria', AI and `cytoplasmic residues' (all P < 0.05). The outcome after embryo transfer was significantly predicted by AI and `fast TRAP'. Semen samples with an AI
ISSN:0268-1161
1460-2350