Studying a ligand substitution reaction with variable temperature 1H NMR spectroscopy

The study of ligand substitution reactions of transition metal complexes is often a significant component of undergraduate courses in inorganic chemistry. In the laboratory, many undergraduates have studied the aquation of [Co(NH3)5Cl]2+at elevated temperatures, taking aliquots of the reaction mixtu...

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Bibliographic Details
Published in:Journal of chemical education 2003-07, Vol.80 (7), p.803
Main Authors: Orvis, Jeffery A, Dimetry, Basant, Winge, Jeffrey, T Corbin Mullis
Format: Article
Language:English
Subjects:
Ammonia
Chemistry
Coordination compounds
High temperature
Ligands
Metal complexes
NMR
NMR spectroscopy
Nuclear magnetic resonance
Organic chemistry
Reaction mechanisms
Spectroscopy
Substitution reactions
Temperature
Transition metal compounds
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Summary:The study of ligand substitution reactions of transition metal complexes is often a significant component of undergraduate courses in inorganic chemistry. In the laboratory, many undergraduates have studied the aquation of [Co(NH3)5Cl]2+at elevated temperatures, taking aliquots of the reaction mixture, and obtaining a series of UV-vis spectra. Recently, an improved synthesis of a similar complex, trans-[Co(NH3)4Cl2]+ was reported. This complex undergoes aquation in less than an hour at room temperature, much faster than [Co(NH3)5Cl]2+, and is readily monitored by 1H NMR spectroscopy. This reaction forms the basis of an instructive, multi-week laboratory experience in inorganic synthesis, followed by an analysis of a reaction mechanism using a classical activation parameter determination.
ISSN:0021-9584
1938-1328