Chemoprevention

Chemoprevention has been shown to be an extremely promising approach to the prevention of invasive cancer. Through the identification of chemopreventive agents that inhibit or reverse the process of carcinogenesis, new strategies of early intervention can be developed for patients at high risk that...

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Bibliographic Details
Published in:CA: a cancer journal for clinicians 1995-01, Vol.45 (1), p.31-49
Main Authors: Greenwald, P, Kelloff, G, Burch-Whitman, C, Kramer, B. S
Format: Article
Language:English
Subjects:
Animals
Anticarcinogenic Agents - therapeutic use
Biomarkers, Tumor
Cancer
Chemotherapy
Clinical trials
Clinical Trials as Topic
Disease Models, Animal
Gene Expression Regulation, Neoplastic - drug effects
Genes, Tumor Suppressor - drug effects
Humans
Medical research
Neoplasms - genetics
Neoplasms - prevention & control
Neoplasms, Experimental - prevention & control
Oncogenes - drug effects
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Summary:Chemoprevention has been shown to be an extremely promising approach to the prevention of invasive cancer. Through the identification of chemopreventive agents that inhibit or reverse the process of carcinogenesis, new strategies of early intervention can be developed for patients at high risk that potentially prevent the onset of invasive and metastatic phases of cancer. This articles reviews the present efforts in chemoprevention research, including the identification of promising agents, screening, and preclinical and clinical evaluations.
ISSN:0007-9235
1542-4863
DOI:10.3322/canjclin.45.1.31