Double-Membrane Sampling System in a Mass Spectrometer for the Study of Exhaled Air

A double-membrane sample-introduction system is described that enables mass spectrometric determination of volatile organic compounds in air, while ensuring their detection limits are as low as a few fractions of ppb of sample composition in real time with a response delay from a few seconds to a fe...

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Bibliographic Details
Published in:Technical physics 2018-10, Vol.63 (10), p.1543-1551
Main Authors: Kogan, V., Antonov, A. S., Chichagov, Yu. V., Victorova-Leclerc, O. S., Victorov, I. V., Kozlenok, A. V.
Format: Article
Language:English
Subjects:
Biomarkers
Classical and Continuum Physics
Computer simulation
Experimental Instruments and Technique
Gas pressure
Physics
Physics and Astronomy
Spectrometry
VOCs
Volatile organic compounds
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Summary:A double-membrane sample-introduction system is described that enables mass spectrometric determination of volatile organic compounds in air, while ensuring their detection limits are as low as a few fractions of ppb of sample composition in real time with a response delay from a few seconds to a few dozens of seconds. It includes two membrane interfaces separated by a volume, the gas pressure in which is maintained through a channel with an adjustable evacuation cross-section. The results of numerical simulation and experimental testing of the system are provided. A technique for selecting and calculating system parameters is described. The possibility of using this system for diagnosing diseases by trace amounts of biomarkers in exhaled air is discussed.
ISSN:1063-7842
1090-6525
DOI:10.1134/S1063784218100146