Physiological and radio-induced modulations of low-weight globulins in distinct vascular compartments

The main goal was to investigate the profiles of molecular weight globulins lower than albumin in the electrophoresis system in function of the exposition time to gamma radiation. At 72 h post-irradiation, the globulin electrophoretic profiles bellow albumin showed significant radio-induced changes....

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2018-11, Vol.318 (2), p.1317-1324
Main Authors: Lima, Celso Vieira, de Campos, Tarcísio Passos Ribeiro, Valencia, Carlos Julio Montano, Almeida, Iassudara Garcia
Format: Article
Language:English
Subjects:
Albumin
Blood proteins
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Electrophoresis
Gamma rays
Gene expression
Globulins
Hadrons
Heavy Ions
Inorganic Chemistry
Ionizing radiation
Kidneys
Molecular weight
Nuclear Chemistry
Nuclear Physics
Physical Chemistry
Physiology
Radio
Spleen
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Summary:The main goal was to investigate the profiles of molecular weight globulins lower than albumin in the electrophoresis system in function of the exposition time to gamma radiation. At 72 h post-irradiation, the globulin electrophoretic profiles bellow albumin showed significant radio-induced changes. In addition, the vascular system, specifically the inferior vena cava, kidney, spleen, jugular, hepatic, and pulmonary veins presented a physiological compartmental distribution of globulins. The findings pointed out the radio-induced alterations of the serum globulin concentrations as a late event, possibly related to a radio modulation of the genes’ expression.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-018-6188-3