Integrated titanium dioxide (TiO2) nanoparticles on interdigitated device electrodes (IDEs) for pH analysis

• Main Authors: Azizah, N., Hashim, U., Arshad, M. K. Md, Gopinath, Subash C. B., Nadzirah, Sh, Farehanim, M. A., Fatin, M. F., Ruslinda, A. R., Ayub, R. M.
• Format: Conference Proceeding
• Language: English
• Subjects: Aminopropyltriethoxysilane; COMPARATIVE EVALUATIONS; CURRENTS; DETECTION; Electrical measurement; Electrical resistivity; ELECTRODES; LAYERS; MODIFICATIONS; NANOPARTICLES; NANOSCIENCE AND NANOTECHNOLOGY; PH VALUE; Protonation; SCREENING; SEMICONDUCTOR MATERIALS; SENSITIVITY; Sensitivity enhancement; SENSORS; Surface charge; SURFACES; Titanium; Titanium dioxide; TITANIUM OXIDES
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/1.4948896

Titanium dioxide (TiO2) nanoparticles based Interdigitated Device Electrodes (IDEs) Nanobiosensor device was developed for intracellular biochemical detection. Fabrication and characterization of pH sensors using IDE nanocoated with TiO2 was studied in this paper. In this paper, a preliminary assessment of this intracellular sensor with electrical measurement under different pH levels. 3-aminopropyltriethoxysilane (APTES) was used to enhance the sensitivity of titanium dioxide layer as well as able to provide surface modification by undergoing protonation and deprotonation process. Different types of pH solution provide different resistivity and conductivity towards the surface. Base solution has the higher current compared to an acid solution. Amine and oxide functionalized TiO2 based IDE exhibit pH-dependent could be understood in terms of the change in surface charge during protonation and deprotonation. The simple fabrication process, high sensitivity, and fast response of the TiO2 based IDEs facilitate their applications in a wide range of areas. The small size of semiconductor TiO2 based IDE for sensitive, label-free, real time detection of a wide range of biological species could be explored in vivo diagnostics and array-based screening.