Synthesis and pharmacological evaluation of newer substituted 2-oxo/thiobarbiturinylbenzoxa/thiazepine derivatives as potent anticonvulsant agents

A new series of 4-(2'-Oxo/thiobarbiturinyl)-2-(substitutedphenyl)-3-[(substitutedaminomethylene)]-2,3-dihydro-1,5-benzothiazepines (5a-5l) and 4-(2'-oxo/thiobarbiturinyl)-2-(substituted-phenyl)-3-(substitute daminomethylene)]-2,3-dihydro-1, 5- benzoxazepines (6a-6l) were synthesized. All t...

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Bibliographic Details
Published in:Oriental journal of chemistry 2015-01, Vol.31 (1), p.121-132
Main Authors: Tyagi, Mirdula, Archana, Archana
Format: Article
Language:English
Subjects:
Acids
Anticonvulsants
Biocompatibility
Convulsions & seizures
Drug dosages
Pharmacology
Sodium
Substitutes
Synthesis
Toxicity
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Summary:A new series of 4-(2'-Oxo/thiobarbiturinyl)-2-(substitutedphenyl)-3-[(substitutedaminomethylene)]-2,3-dihydro-1,5-benzothiazepines (5a-5l) and 4-(2'-oxo/thiobarbiturinyl)-2-(substituted-phenyl)-3-(substitute daminomethylene)]-2,3-dihydro-1, 5- benzoxazepines (6a-6l) were synthesized. All the newly synthesized compounds were screened in vivo, for their acute toxicity and anticonvulsant activity in MES and PTZ models and were compared with standard drugs phenytoin sodium and sodium valporate. Out of the compounds studied, the most active compound of this series was 5 h, showed activity (90%) more potent than the standard drug.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/310113