Synthesis of Acetylated Dihydropyrimidine Analogues Under Solvent Free Conditions and their Evaluation as Calcium Channel Blockers

One pot condensation of ethylacetoacetate with various para and ortho substituted aldehydes and urea or thiourea by SnCl2.2H2O affords eight different substituted 3,4-dihydropyrimidine ones/thiones. Further we prepared acetylated 3,4-dihydropyrimidine ones/thiones, on treatment of 3,4-dihydropyrimid...

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Bibliographic Details
Published in:Oriental journal of chemistry 2012-01, Vol.28 (2), p.1055-1059
Main Authors: SATI, BHAWANA, ELLAMMA, ELLAMMA, SATI, HEMLATA, NARGUND, L.V.G., KHAIDEM, SOMILA, BHATT, PRAKASH CHANDRA, SAKLANI, SARLA
Format: Article
Language:English
Subjects:
Aldehydes
Anhydrides
Calcium channel blockers
Calcium chloride
Calcium compounds
Chemical synthesis
Substitutes
Zinc chloride
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Summary:One pot condensation of ethylacetoacetate with various para and ortho substituted aldehydes and urea or thiourea by SnCl2.2H2O affords eight different substituted 3,4-dihydropyrimidine ones/thiones. Further we prepared acetylated 3,4-dihydropyrimidine ones/thiones, on treatment of 3,4-dihydropyrimidine ones/thiones with acetic anhydride using zinc chloride as a catalyst. Calcium channel blocker activity shows that synthesized compounds have moderate activity.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/280259