Synthesis of Acetylated Dihydropyrimidine Analogues Under Solvent Free Conditions and their Evaluation as Calcium Channel Blockers

One pot condensation of ethylacetoacetate with various para and ortho substituted aldehydes and urea or thiourea by SnCl2.2H2O affords eight different substituted 3,4-dihydropyrimidine ones/thiones. Further we prepared acetylated 3,4-dihydropyrimidine ones/thiones, on treatment of 3,4-dihydropyrimid...

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Published in:Oriental journal of chemistry 2012-01, Vol.28 (2), p.1055-1059
Main Authors: SATI, BHAWANA, ELLAMMA, ELLAMMA, SATI, HEMLATA, NARGUND, L.V.G., KHAIDEM, SOMILA, BHATT, PRAKASH CHANDRA, SAKLANI, SARLA
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Language:English
Subjects:
Aldehydes
Anhydrides
Calcium channel blockers
Calcium chloride
Calcium compounds
Chemical synthesis
Substitutes
Zinc chloride
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container_end_page 1059
container_issue 2
container_start_page 1055
container_title Oriental journal of chemistry
container_volume 28
creator SATI, BHAWANA
ELLAMMA, ELLAMMA
SATI, HEMLATA
NARGUND, L.V.G.
KHAIDEM, SOMILA
BHATT, PRAKASH CHANDRA
SAKLANI, SARLA
description One pot condensation of ethylacetoacetate with various para and ortho substituted aldehydes and urea or thiourea by SnCl2.2H2O affords eight different substituted 3,4-dihydropyrimidine ones/thiones. Further we prepared acetylated 3,4-dihydropyrimidine ones/thiones, on treatment of 3,4-dihydropyrimidine ones/thiones with acetic anhydride using zinc chloride as a catalyst. Calcium channel blocker activity shows that synthesized compounds have moderate activity.
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subjects Aldehydes
Anhydrides
Calcium channel blockers
Calcium chloride
Calcium compounds
Chemical synthesis
Substitutes
Zinc chloride
title Synthesis of Acetylated Dihydropyrimidine Analogues Under Solvent Free Conditions and their Evaluation as Calcium Channel Blockers
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