Zn[(L)-proline]2: A Novel and Recyclable Catalyst for the Synthesis of 2-Aryl-4(3H)-quinazolinones in Solvent-Free Conditions

An efficient, solvent-free and facile synthesis of 3-aryl quinazolinones from cyclocondensation of 2-aminobenzamides with aryl aldehydes catalyzed by Zn[(L)-proline]2 in the presence of CuCl2 is described. The salient features of the reaction include good yields , mild reaction conditions , low load...

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Bibliographic Details
Published in:Oriental journal of chemistry 2012-01, Vol.28 (1), p.399
Main Authors: Montazeri, Naser, Khalil Pourshamsian, Fouladi, Mahdi, Bayazi, Masoud
Format: Article
Language:English
Subjects:
Aldehydes
Aromatic compounds
Catalysis
Catalysts
Chemical synthesis
Proline
Quinazolinones
Solvents
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Summary:An efficient, solvent-free and facile synthesis of 3-aryl quinazolinones from cyclocondensation of 2-aminobenzamides with aryl aldehydes catalyzed by Zn[(L)-proline]2 in the presence of CuCl2 is described. The salient features of the reaction include good yields , mild reaction conditions , low loading of catalyst , and operational simplicity. The catalyst is reusable and can be applied several times without considerable decrease in the yields and rates of the reactions.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/280150