Ammonium Chloride: An Effective Catalyst for the One-pot Synthesis of 2,4,5-Trisubstituted Imidazoles

An efficient synthesis of 2,4,5-trisubstituted imidazoles is achieved by three component cyclocondensation of 1,2-dicarbonyl compound, aldehyde and ammonium acetate using Ammonium chloride (NH4Cl) as a catalyst. The key advantages of this process are high yields, cost effectiveness of catalyst, easy...

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Bibliographic Details
Published in:Oriental journal of chemistry 2012-09, Vol.28 (3), p.1207-1212
Main Authors: MALEKI, BEHROOZ, KESHVARI, HOSSEIN, MOHAMMADI, ALI
Format: Article
Language:English
Subjects:
Ammonium acetate
Ammonium chloride
Carbonyl compounds
Catalysis
Catalysts
Chemical synthesis
Chromatography
Cost effectiveness
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Summary:An efficient synthesis of 2,4,5-trisubstituted imidazoles is achieved by three component cyclocondensation of 1,2-dicarbonyl compound, aldehyde and ammonium acetate using Ammonium chloride (NH4Cl) as a catalyst. The key advantages of this process are high yields, cost effectiveness of catalyst, easy work-up and purification of products by non-chromatographic method.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/280316