Patient Perspectives on Adherence to the New Hepatitis C Antiviral Medications: ‘A New Lease on Life’

This study explored patients’ perspectives about taking the new direct-acting antivirals (DAAs) for the treatment of Hepatitis C (i.e., sofosbuvir, simeprevir, ledipasvir/sofosbuvir, ombitasvir/paritraprevir/ritonavir and dasabuvir) to identify facilitators of medication adherence. The project was c...

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Bibliographic Details
Published in:Qualitative report 2018-01, Vol.23 (1), p.184-203
Main Authors: Giordano, Nicole, Brinn, Anthony, Garcia-Tsao, Guadalupe, Martino, Steve
Format: Article
Language:English
Subjects:
Antiviral agents
Beliefs, opinions and attitudes
Blood diseases
Cancer
Chronic illnesses
Coding
Death
Disease control
Dosage and administration
Drug therapy
Gastroenterology
Genotype & phenotype
Guidelines
Health Behavior
Health care expenditures
Hepatitis
Hepatitis C
Hepatology
HIV
Hospital administration
Human immunodeficiency virus
Infections
Infectious diseases
Interviews
Liver cancer
Liver diseases
Medical research
Medical Services
Mental health
Mortality
Nurse practitioners
Osteoporosis
Outcomes of Treatment
Patient compliance
Patients
Pharmaceutical industry
Physician Patient Relationship
Private Sector
Public health
Qualitative Research
Resistance (Psychology)
Semi Structured Interviews
Structured Interviews
Substance Abuse
Treatment compliance
Veterans
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Summary:This study explored patients’ perspectives about taking the new direct-acting antivirals (DAAs) for the treatment of Hepatitis C (i.e., sofosbuvir, simeprevir, ledipasvir/sofosbuvir, ombitasvir/paritraprevir/ritonavir and dasabuvir) to identify facilitators of medication adherence. The project was conducted using semi-structured interviews with 12 Veterans who successfully completed a treatment course on the new DAAs. The Veterans were recruited using purposive sampling. The data collected from the semi-structured interviews was analyzed using an adapted open coding method outlined by Auerbach and Silverstein (2003), with identification of relevant text sub-grouped into repeating ideas, and then creation of overarching themes and constructs. Results obtained provide insight into factors that influenced the Veterans’ medication adherence during the course of treatment. Key constructs, embodying major themes supported by repeating ideas, included recognizing the “burden of HCV,” the importance of the “treatment engagement process,” and anticipation of “positive outcomes.” Clinical implications are discussed.
ISSN:1052-0147
2160-3715
DOI:10.46743/2160-3715/2018.2740