Development of New Spectrophotometric Methods for The Determination of Alfuzosin Hydrochloride in Bulk and Pharmaceutical Formulations

Two simple and sensitive methods A and B for the spectrophotometric determination of Alfuzosin hydrochloride have been described. These methods are based on the formation of purple color and red- violet colored chromogens obtained when the drug was diazotized with nitrous acid followed by coupling w...

Full description

Saved in:
Bibliographic Details
Published in:Oriental journal of chemistry 2008-01, Vol.24 (2), p.725
Main Authors: Kumar, D Ravi, Vardhan, S V M, Ramachandran, D, Rambabu, C
Format: Article
Language:English
Subjects:
Formulations
Nitrous acid
Pharmaceuticals
Phloroglucinol
Spectrophotometry
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two simple and sensitive methods A and B for the spectrophotometric determination of Alfuzosin hydrochloride have been described. These methods are based on the formation of purple color and red- violet colored chromogens obtained when the drug was diazotized with nitrous acid followed by coupling with Phloroglucinol and Resorcinol, exhibiting lmax at 520 and 600 nm respectively. These methods obey Beer’s law in the concentration ranges of 4-20 and 2-10 μg/mL. These methods are highly reproducible and have been applied to a wide variety of pharmaceutical preparations.
ISSN:0970-020X
2231-5039